Case report of a rare case of Kleine Levin Syndrome in Schizophrenia

  • Robert David Hogg, D.O. Oklahoma State University Medical Center
  • Vamsi Guda, D.O. Oklahoma State University Medical Center
  • Justin Chronister, D.O. Oklahoma State University Medical Center
Keywords: Hypersomnia, Kleine Levin, catatonia, schizophrenia, sleeping beauty syndrome

Abstract

Kleine Levine syndrome is classically described with hypersomnia, hyperphagia, psychotic features and disinhibited behavior. The patient in question demonstrated several months of psychosis and then presented with features consistent with KLS to the tertiary care center. Extensive evaluation was undertaken to rule out organic causes of the patient’s condition. With features consistent with KLS, the patient was initiated on Lithium with improvement in clinical condition over a course of 2 weeks. In patients presenting with features of KLS it is important to have a high degree of suspicion and initiate therapy with lithium.

References

Arnulf I, Zeitzer JM, File J, Farber N, Mignot E. Kleine-Levin syndrome: A systematic review of 186 cases in the literature. Brain 2005;128:2763-76.

American Academy of Sleep Medicine. International classification of

sleep disorders, revised: Diagnostic and coding manual. Chicago, Illinois: American

Academy of Sleep Medicine, 2001

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.).Jun 21, 2016

Cheung, G. et al. Posttraumatic Kleine–Levin syndrome. General Hospital Psychiatry 28 (2006) 443–445

Fenzi F, Simonati A, Crosato F, Ghersini L, Rizzuto N. Clinical features of

Kleine–Levin syndrome with localized encephalitis. Neuropediatrics 1993;

: 292–5.

Lobzin VS, Shamrei RK, Churilov Iu K. Pathophysiologic mechanisms of

periodic sleep and the Kleine–Levin syndrome. Zh Nevropatol Psikhiatr

Im S S Korsakova 1973; 73: 1719–24

Murthy VS, Kelkar AD, Sonavane SS. Psychosis in a case of Kleine-Levin syndrome: A diagnostic challenge. Indian J Psychol Med 2014;36:192-4.

Sadock, Benjamin J., Harold I. Kaplan, and Virginia A. Sadock. Kaplan & Sadock's Synopsis of Psychiatry: Behavioral Sciences/clinical Psychiatry. Philadelphia: Wolter Kluwer/Lippincott Williams & Wilkins, 2007. Print.

Takrani LB, Cronin D. Kleine–Levin syndrome in a female patient. Can

Psychiatr Assoc J 1976; 21: 315–8.

Testa S, Opportuno A, Gallo P, Tavolato B. A case of multiple sclerosis with

an onset mimicking the Kleine–Levin syndrome. Ital J Neurol Sci 1987;

: 151–5

Published
2018-09-07
Section
Medical